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ChemicalBook CAS DataBase List Lapatinib iMpurity
746591-42-4

Lapatinib iMpurity synthesis

5synthesis methods
Benzene, 1-fluoro-3-[(4-nitrophenoxy)methyl]-

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Lapatinib iMpurity

746591-42-4
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Yield:-

Steps:

Multi-step reaction with 3 steps
1: H2 / Pt/C / ethanol; tetrahydrofuran
2: propan-2-ol / 70 °C
3: Pd(OAc)2; PPh3; Et3N / dimethylformamide

References:

Petrov, Kimberly G.;Zhang, Yue-Mei;Carter, Malcolm;Cockerill, G. Stuart;Dickerson, Scott;Gauthier, Cassandra A.;Guo, Yu;Mook Jr., Robert A.;Rusnak, David W.;Walker, Ann L.;Wood, Edgar R.;Lackey, Karen E. [Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,# 17,p. 4686 - 4691]

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