L-SERINE(BENZYL ETHER) ETHYL ESTER HCL synthesis
- Product Name:L-SERINE(BENZYL ETHER) ETHYL ESTER HCL
- CAS Number:58178-57-7
- Molecular formula:C12H18ClNO3
- Molecular Weight:259.73
23680-31-1
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Yield:58178-57-7 100%
Reaction Conditions:
with thionyl chloride in ethanol at 78; for 4 h;
Steps:
L-Ser(OBn)-OEt * HCl (37).
N-Boc-O-benzyl-L-serine (2.00 g; 6.76 mmol) was dissolved in EtOH (80 mL)and thionyl chloride (1.47 mL; 20.3 mmol) was added drop-wise to the solution. After stirring for 4 h at 78 °Cthe solvent was removed in vacuo to give analytically pure 37 (1.75 g; quant.) as colorless solid
References:
Siebert, David C.B.;Sommer, Roman;Pogorevc, Domen;Hoffmann, Michael;Wenzel, Silke C.;Müller, Rolf;Titz, Alexander [Beilstein Journal of Organic Chemistry,2019,vol. 15,p. 2922 - 2929] Location in patent:supporting information
4726-96-9
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