Idarubicin synthesis
- Product Name:Idarubicin
- CAS Number:58957-92-9
- Molecular formula:C26H27NO9
- Molecular Weight:497.49
23541-50-6
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Yield:-
Steps:
Multi-step reaction with 5 steps
1.1: potassium carbonate; triflic azide / dichloromethane; water; methanol
2.1: potassium iodide; magnesium chloride / tetrahydrofuran / 1.5 h / 40 °C
2.2: pH 2.5 / Cooling with ice
3.1: N-ethyl-N,N-diisopropylamine; pyridine / dmap / 1 h / 0 - 20 °C
4.1: triethylammonium formate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 8 h / 50 °C / Inert atmosphere
5.1: triphenylphosphine / tetrahydrofuran
References:
Synbias Pharma Ltd. EP2518077, 2012, A1
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60660-75-5
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