Daunorubicin hydrochloride
- $15 - $1340
- Product name: Daunorubicin hydrochloride
- CAS: 23541-50-6
- MF: C27H29NO10.ClH
- MW: 563.98
- EINECS:245-723-4
- MDL Number:MFCD04974507
- Synonyms:5,12-Naphthacenedione,8-acetyl-10-[(3-aMino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-Methoxy-,hydrochloride (1:1), (8S,10S)-;daunoblastin ;daunoblastina ;daunomycinchlorohydrate ;ndc0082-4155 ;ondena ;rp13057hydrochloride ;rubidomycinhydrochloride
60 prices
Selected condition:
Brand
- AK Scientific
- Alfa Aesar
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Biorbyt Ltd
- Cayman Chemical
- Chem-Impex
- ChemScene
- Chemtos
- Crysdot
- CSNpharm
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- d0125000
- 1mg
- 20mg
- 10
- 5MG
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 500mg
- 1000mg
- 1g
- 5g
- ManufacturerAK Scientific
- Product numberQ716
- Product descriptionDaunorubicinHCl
- Packaging50mg
- Price$144
- Updated2021-12-16
- Buy
- ManufacturerAlfa Aesar
- Product numberJ60224
- Product descriptionDaunorubicin hydrochloride
- Packaging10mg
- Price$214
- Updated2024-03-01
- Buy
- ManufacturerAmbeed
- Product numberA148164
- Product description(8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride 98+%
- Packaging10mg
- Price$15
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA148164
- Product description(8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride 98+%
- Packaging25mg
- Price$18
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA148164
- Product description(8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride 98+%
- Packaging50mg
- Price$22
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA148164
- Product description(8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride 98+%
- Packaging100mg
- Price$27
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA148164
- Product description(8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride 98+%
- Packaging250mg
- Price$53
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA148164
- Product description(8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride 98+%
- Packaging1g
- Price$149
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA148164
- Product description(8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride 98+%
- Packaging5g
- Price$596
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0002223
- Product descriptionDAUNORUBICIN HYDROCHLORIDE 95.00%
- Packaging1G
- Price$675.15
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0002223
- Product descriptionDAUNORUBICIN HYDROCHLORIDE 95.00%
- Packaging5MG
- Price$508
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2285
- Product descriptionDaunorubicinHCl
- Packaging10mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS003082
- Product description(8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride ≥98%
- Packaging5g
- Price$590
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60137
- Product descriptionDaunorubicinHCl
- Packaging20mg
- Price$178
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS003082
- Product description(8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride ≥98%
- Packaging1g
- Price$148
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS003082
- Product description(8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride ≥98%
- Packaging250mg
- Price$52
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
AK Scientific | Q716 | DaunorubicinHCl | 50mg | $144 | 2021-12-16 | Buy |
Alfa Aesar | J60224 | Daunorubicin hydrochloride | 10mg | $214 | 2024-03-01 | Buy |
Ambeed | A148164 | (8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride 98+% | 10mg | $15 | 2021-12-16 | Buy |
Ambeed | A148164 | (8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride 98+% | 25mg | $18 | 2021-12-16 | Buy |
Ambeed | A148164 | (8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride 98+% | 50mg | $22 | 2021-12-16 | Buy |
Ambeed | A148164 | (8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride 98+% | 100mg | $27 | 2021-12-16 | Buy |
Ambeed | A148164 | (8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride 98+% | 250mg | $53 | 2021-12-16 | Buy |
Ambeed | A148164 | (8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride 98+% | 1g | $149 | 2021-12-16 | Buy |
Ambeed | A148164 | (8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride 98+% | 5g | $596 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0002223 | DAUNORUBICIN HYDROCHLORIDE 95.00% | 1G | $675.15 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0002223 | DAUNORUBICIN HYDROCHLORIDE 95.00% | 5MG | $508 | 2021-12-16 | Buy |
ApexBio Technology | B2285 | DaunorubicinHCl | 10mg | $50 | 2021-12-16 | Buy |
Arctom | AS003082 | (8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride ≥98% | 5g | $590 | 2021-12-16 | Buy |
Arctom | CFN60137 | DaunorubicinHCl | 20mg | $178 | 2021-12-16 | Buy |
Arctom | AS003082 | (8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride ≥98% | 1g | $148 | 2021-12-16 | Buy |
Arctom | AS003082 | (8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride ≥98% | 250mg | $52 | 2021-12-16 | Buy |
Properties
Melting point :190°C (dec)
alpha :D20 +248 ±5° (c = 0.05-0.1 in methanol)
storage temp. :Inert atmosphere,2-8°C
solubility :Freely soluble in water and in methanol, slightly soluble in alcohol, practically insoluble in acetone.
form :solid
color :red to deep red
Water Solubility :Soluble in water (50 mM)
λmax :477nm(H2O)(lit.)
Sensitive :Hygroscopic
Merck :14,2832
BRN :4229221
Stability :Stability
InChIKey :GUGHGUXZJWAIAS-SMLRDAARNA-N
SMILES :C1=CC2C(=O)C3=C(O)C4C[C@](C(C)=O)(O)C[C@H](O[C@@H]5O[C@@H](C)[C@@H](O)[C@@H](N)C5)C=4C(O)=C3C(=O)C=2C(OC)=C1.Cl |&1:10,16,18,20,22,24,r|
EPA Substance Registry System :Daunorubicin hydrochloride (23541-50-6)
alpha :D20 +248 ±5° (c = 0.05-0.1 in methanol)
storage temp. :Inert atmosphere,2-8°C
solubility :Freely soluble in water and in methanol, slightly soluble in alcohol, practically insoluble in acetone.
form :solid
color :red to deep red
Water Solubility :Soluble in water (50 mM)
λmax :477nm(H2O)(lit.)
Sensitive :Hygroscopic
Merck :14,2832
BRN :4229221
Stability :Stability
InChIKey :GUGHGUXZJWAIAS-SMLRDAARNA-N
SMILES :C1=CC2C(=O)C3=C(O)C4C[C@](C(C)=O)(O)C[C@H](O[C@@H]5O[C@@H](C)[C@@H](O)[C@@H](N)C5)C=4C(O)=C3C(=O)C=2C(OC)=C1.Cl |&1:10,16,18,20,22,24,r|
EPA Substance Registry System :Daunorubicin hydrochloride (23541-50-6)
Safety Information
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Signal word: | Danger | ||||||||||||||||||||||||||||
Hazard statements: |
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Precautionary statements: |
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Description
Daunorubicin is an antitumor antibiotic widely used in the treatment of acute myeloid leukemias (AMLs). At 0.2-1μM, daunorubicin induces apoptosis in mature monocytic U937 and myelocytic HL-60 AML cells. However, immature AML cells (CD 34+-KG1a, -KG1, or -HEL cells) appear resistant to apoptosis at similar concentrations. In mature AML cells, daunorubicin has been shown to trigger a ROS-dependent sphingomyelin-ceramide pathway that activates the MEKK1-SEK1-JNK cascade leading to enhanced DNA binding activity of the transcription factor AP-1.More related product prices
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