ChemicalBook CAS DataBase List Homovanillic acid

Homovanillic acid synthesis

13synthesis methods

Product Name:Homovanillic acid
CAS Number:306-08-1
Molecular formula:C9H10O4
Molecular Weight:182.17

55-10-7 Synthesis

55-10-7
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$19.00/250mg

306-08-1
358 suppliers
$10.00/1g

Yield:306-08-1 88%

Reaction Conditions:

with hydrogenchloride;tin(ll) chloride in water at 80; for 4 h;

Steps:

1.1.2 1.1.2 Synthesis process of intermediate compound a3
First, stannous chloride dihydrate (250 mmol, 2 eq) was dissolved in 120 ml of concentrated hydrochloric acid.To be completely dissolved, the compound 2-(3-ethoxy-4-hydroxyphenyl)-2-hydroxyacetic acid (94 mmol, 1 eq) was added to a hydrochloric acid solution of stannous chloride dihydrate and reacted at 80 ° C for 4 h. The reaction was stopped, cooled to room temperature, and a white solid was precipitated and crystallised from distilled water to give 16.3 g of 2-(3-ethoxy-4-hydroxyphenyl)acetic acid as a white solid.

References:

Wuhan Jiayu Technology Co., Ltd.;Zhang Guisen;Zhang Heng;Liu Bifeng CN104262292, 2019, B Location in patent:Paragraph 0059; 0065; 0066

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4468-59-1 Synthesis