methyl 2-(benzylamino)acetate synthesis

4synthesis methods

Product Name:methyl 2-(benzylamino)acetate
CAS Number:17136-35-5
Molecular formula:C10H14ClNO2
Molecular Weight:215.68

67-56-1 Synthesis

67-56-1
754 suppliers
$7.29/5ml-f

17136-36-6 Synthesis

17136-36-6
231 suppliers
$10.00/1g

17136-35-5
55 suppliers
$29.12/1G

Yield: 99%

Reaction Conditions:

with hydrogenchloride in 1,4-dioxane

Steps:

9.1
Step 1 : Methyl 2-(benzylamino)acetate hydrochloride (27). To a N-benzyl glycine 26 (500 mg, 3.0 mmol) in MeOH (6 mL) was added 4M solution of HCl in dioxane (4 mL) and stirred overnight. The reaction mixture was concentrated to afford compound 27 (649mg, 99%) as a white solid. The crude compound was carried forward without further purification. LRMS (ESI): (calc) 179.2 (found) 180.1(MH)+.

References:

METHYLGENE INC. WO2008/122115, 2008, A1 Location in patent:Page/Page column 52

6436-90-4 Synthesis