成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Fluticasone propionate
80474-14-2

Fluticasone propionate synthesis

8synthesis methods
Fluticasone propionate, synthesized by Glaxo Wellcome and launched in 1993, is a trifluorinated glucocorticosteroid. It shows good topical antiinflammatory activity and is commonly used as a safe and effective inhaled treatment for asthma and allergic rhinitis.
synthesis of fluticasone propionate
Fluticasone propionate can be synthesized from 9 by using BrCH2F,2a ClCH2F,5a or S-(monofluoromethyl) diarylsulfonium tetrafluoroborate 5f,g directly. Using BrCH2F can get an ideal yield; however, BrCH2F is costly and will destroy to the ozone layer. In addition, 9 reacted with BrCH2Cl or Br2CH2 and then by an anion exchange with AgF,2c,5e KF, or tetrabutylammonium fluoride5b to afford 1 in a low yield.
Improved Synthesis of Fluticasone Propionate
-

Yield:80474-14-2 91.7%

Reaction Conditions:

with potassium hydrogencarbonate in N,N-dimethyl-formamide at -10 - 20; for 2 h;

Steps:

1-11 Substitution into ester reaction:

In a four-necked bottle, add 31.7g IM4 and 159ml dimethylformamide, lower the temperature to below 20 , add 7.2g potassium bicarbonate,Then lower the temperature to below -10 ,Add 8.7g of fluorobromomethane dropwise,Then control the temperature -10-20 for 2 hours, after the IM4 reaction is detected by HPLC, add 1mol / L hydrochloric acid dropwise, adjust the PH value to 2, crystallize, filter, wash and dry to obtain 32.5g crude fluticasone propionate, this step The molar yield is 96.3%.Refining reaction: In a four-necked bottle, add 31.2g crude fluticasone propionate and 437ml acetone, raise the temperature to 55 , stir to dissolve, control the temperature 50-60 , add 250ml of purified water dropwise, then slowly lower the temperature Crystallization below 15 , filtration, washing and drying to obtain 28.6g crude fluticasone propionate, the molar yield of this step is 91.7%.

References:

CN110698530,2020,A Location in patent:Page/Page column 7-15

Fluticasone propionate Related Search: