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ChemicalBook CAS DataBase List ethyl2,2-difluoro-2-(quinolin-6-yl)acetate
943541-40-0

ethyl2,2-difluoro-2-(quinolin-6-yl)acetate synthesis

6synthesis methods
2- ketone -6- ethyl acetate

1093204-29-5
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ethyl2,2-difluoro-2-(quinolin-6-yl)acetate

943541-40-0
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Yield:943541-40-0 83%

Reaction Conditions:

with diethylamino-sulfur trifluoride in ethanol;dichloromethane at 39;Inert atmosphere;

References:

Aronov, Alex M.;Boucher, Diane;Deininger, David D.;Ford, Pamella J.;Giroux, Simon;Lauffer, David J.;Li, Pan;Liang, Jianglin;McGinty, Kira;Moody, Cameron S.;Ronkin, Steven;Swett, Rebecca;Tang, Qing;Waal, Nathan [ACS Medicinal Chemistry Letters,2021,vol. 12,# 6,p. 955 - 960] Location in patent:supporting information

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