ETHYL THIOPHENE-2-GLYOXYLATE synthesis
- Product Name:ETHYL THIOPHENE-2-GLYOXYLATE
- CAS Number:4075-58-5
- Molecular formula:C8H8O3S
- Molecular Weight:184.21
33898-90-7
174 suppliers
$8.00/1g
64-17-5
730 suppliers
$10.00/50g
4075-58-5
108 suppliers
$19.00/1g
Yield: 82%
Reaction Conditions:
with [bis(acetoxy)iodo]benzene in dichloromethane for 2 h;Reflux;
Steps:
Ethyl 2-thienylglyoxylate 3m
General procedure: β-Oxo-benzenepropanenitrile 1(1.0 mmol),PIDA (2.2 mmol) were dissolved in EtOH (8 mL) and stirred under refluxing for 0.5h. After the reaction was completed (monitored by TLC), thereaction mixture was concentrated under vacuum. The residue was purified by chromatographyon silica gel (20:1 petroleum ether/EtOAc) to give the product 3a-o .Thesolvent for the synthesis of 3o was MeOH.
References:
Xie, Yuanyuan;Liu, Jiwei;Huang, Yingyi;Yao, Lixia [Tetrahedron Letters,2015,vol. 56,# 24,p. 3793 - 3795] Location in patent:supporting information
5713-61-1
46 suppliers
$238.00/50mL
95-92-1
421 suppliers
$5.00/5 g
4075-58-5
108 suppliers
$19.00/1g
1003-09-4
483 suppliers
$10.00/25g
95-92-1
421 suppliers
$5.00/5 g
4075-58-5
108 suppliers
$19.00/1g
