Ethyl pyrazole-4-carboxylate synthesis
- Product Name:Ethyl pyrazole-4-carboxylate
- CAS Number:37622-90-5
- Molecular formula:C6H8N2O2
- Molecular Weight:140.14
37718-11-9
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64-17-5
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$10.00/50g
37622-90-5
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Yield:37622-90-5 80%
Reaction Conditions:
with thionyl chloride at 0 - 20; for 3 h;
Steps:
29 ethyl 1H-pyrazole-4-carboxylate (50-2)
[0134] To a solution of 1H-pyrazole-4-carboxylic acid (50-1, 1 g, 8.92 mmol) in EtOH (10 mL) was added thionyl chloride (1.6 g, 13.38 mmol) at 0oC and the mixture was stirred at rt for 3h. The progress of the reaction was monitored by TLC. After completion of the reaction, all the volatiles were evaporated to dryness. The mixture was diluted with water and extracted with EtOH/DCM (10%). The combined organic layers were washed with water and brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude compound was purified by silica gel column chromatography (15% EtOAc/hexane) to afford compound 50-2 (1.0 g, 80.0%) as an off white solid. LC-MS: m/z 141. 0 [M+H]+.
References:
WO2021/102410,2021,A1 Location in patent:Paragraph 0134
80370-42-9
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37622-90-5
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6994-25-8
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37622-90-5
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141573-95-7
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37622-90-5
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105-56-6
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37622-90-5
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