Ethyl 3-amino-4-pyrazolecarboxylate synthesis
- Product Name:Ethyl 3-amino-4-pyrazolecarboxylate
- CAS Number:6994-25-8
- Molecular formula:C6H9N3O2
- Molecular Weight:155.15
144918-37-6
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Yield:6994-25-8 99%
Reaction Conditions:
with hydrazine in ethanol at 20;Reflux;
Steps:
To a stirred solution of ethyl (E)-2-cyano-3-ethoxyacrylate (5 g, 29.5 mmol) in ethanol (50 mL) wasadded hydrazine (1.8 mL, 29.5 mmol) dropwise. The mixture was stirred at room temperature for10 mins and was heated to reflux overnight. The solvent was removed in vacuo and the residue wasextracted with ethyl acetate, washed with H2O and brine. The water layer was extracted withethyl acetate for three times. The organic phase was dried over anhydrous sodium sulfate,filtered, and concentrated to afford compound 42a as light-yellow solid (4.54 g, 99%).
References:
Chen, Yun;Bai, Gang;Ning, Yi;Cai, Shi;Zhang, Tao;Song, Peiran;Zhou, Jinpei;Duan, Wenhu;Ding, Jian;Xie, Hua;Zhang, Huibin [European Journal of Medicinal Chemistry,2020,vol. 190,art. no. 112092] Location in patent:supporting information
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6630-64-4
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42466-67-1
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94-05-3
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6994-25-8
403 suppliers
$5.00/1g