ChemicalBook CAS DataBase List Ethyl alpha-Formyl Benzeneacetic Acid Ester

Ethyl alpha-Formyl Benzeneacetic Acid Ester synthesis

6synthesis methods

Product Name:Ethyl alpha-Formyl Benzeneacetic Acid Ester
CAS Number:17838-69-6
Molecular formula:C11H12O3
Molecular Weight:192.21

Use ethyl phenylacetate and ethyl formate to condense under the participation of metallic sodium to generate α-(sodium methacrylate) ethyl phenylacetate, and then acidify to obtain Ethyl-2-formyl-2-phenylacetate.

107-31-3
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101-97-3 Synthesis

101-97-3
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Ethyl alpha-Formyl Benzeneacetic Acid Ester

17838-69-6
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Yield: 92%

Reaction Conditions:

with diisopropyl-carbodiimide in toluene at 40 - 50;

Steps:

3.3 Example 3
(3) Ethyl phenylacetate, methyl formate and diisopropylcarbodiimide are added into toluene and reacted at 40-50° C. for 2-3 h.After the reaction was completed, deionized water was added dropwise to the reaction solution. After completion of the dropwise addition, the layers were allowed to stand for separation. The aqueous layer was separated, extracted with toluene, and the toluene solution was combined. The solution was washed with saturated NaCl and distilled under reduced pressure to collect 83-85°C. /199Pa,be made ofEthyl α-formylphenylacetate, yield 92.0%;Wherein, the molar ratio of ethyl phenylacetate, methyl formate and diisopropylcarbodiimide is 1:1.6:2;

References:

Suzhou Gaide Careful Materials Co., Ltd.;Li Xiaoming CN107892645, 2018, A Location in patent:Paragraph 0021-0025; 0027-0031; 0033-0037; 0039-0049

101-97-3 Synthesis

101-97-3
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109-94-4 Synthesis