ETHYL 3,4,5-TRIMETHOXYPHENYL ACETATE synthesis
- Product Name:ETHYL 3,4,5-TRIMETHOXYPHENYL ACETATE
- CAS Number:66162-60-5
- Molecular formula:C13H18O5
- Molecular Weight:254.28
Yield:66162-60-5 99%
Reaction Conditions:
with sulfuric acid in toluene;Reflux;
Steps:
1 Example 1: Ethyl 2- (3,4,5-trimethoxyphenyl) acetate (1).
2- (3,4,5-trimethoxyphenyl)Acetic acid (90.5 g, 0.4 mol),Anhydrous ethanol (120 mL) and concentratedH2SO4 (8 mL) was added to toluene (500 mL)Reflux overnightWater Separator.After completion of the reaction,EtOAc (400 mL), Washed sequentially with 1 N aqueous NaOH (50 mL) and brine,Na2SO4 dried,Concentration under reduced pressure gave compound 1 as pale yellowOil (100.6 g, 99% yield).1H NMR (300 MHz, CDCl3)? 6.52 (s, 2H), 4.18 (q, J = 7.1 Hz, 2H)3.87 (s, 6H), 3.85 (s, 3H), 3.56 (s, 2H), 1.29 (t, J = 7.1 Hz, 3H) .ESI-MS m / z = 255.24 [M + 1
References:
CN104649879,2017,B Location in patent:Paragraph 0069; 0070
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![Benzene, 1,2,3-trimethoxy-5-[2-(methylsulfinyl)-2-(methylthio)ethenyl]-](/CAS/20210305/GIF/69187-05-9.gif)