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22531-51-7

ETHYL 2-METHOXY-1-NAPHTHOYLFORMATE synthesis

3synthesis methods
-

Yield:22531-51-7 80%

Reaction Conditions:

Stage #1: 4-chloro-1-methyl-naphthalenewith lithium in diethyl ether at 20; for 3 h;
Stage #2: with copper(l) cyanide in tetrahydrofuran;diethyl ether; for 0.25 h;Cooling with ice;
Stage #3: Ethyl oxalyl chloride in tetrahydrofuran;diethyl ether; for 0.666667 h;Cooling with ice;

References:

Screttas, Constantinos G.;Steele, Barry R.;Micha-Screttas, Maria;Heropoulos, Georgios A. [Organic Letters,2012,vol. 14,# 22,p. 5680 - 5683] Location in patent:supporting information

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