ChemicalBook CAS DataBase List epiberberine

epiberberine synthesis

4synthesis methods

Product Name:epiberberine
CAS Number:6873-09-2
Molecular formula:C20H18NO4+
Molecular Weight:336.3612

6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE

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Yield:-

Steps:

Multi-step reaction with 7 steps
1: copper(l) iodide; benzoic acid / toluene / 12 h / 80 °C / Inert atmosphere; Molecular sieve
2: potassium carbonate / methanol / 0.5 h / 20 °C / Inert atmosphere
3: sodium formate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 1 h / 100 °C / Inert atmosphere
4: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 2 h / 50 °C / Inert atmosphere; Molecular sieve
5: Wilkinson's catalyst; diphenyl phosphoryl azide / diethylene glycol dimethyl ether / 12 h / 160 °C / Inert atmosphere
6: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2 h / Reflux; Inert atmosphere
7: potassium acetate; iodine / ethanol / 20 °C / Inert atmosphere

References:

Zhou, Shiqiang;Tong, Rongbiao [Chemistry - A European Journal,2016,vol. 22,# 21,p. 7084 - 7089]

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