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ChemicalBook CAS DataBase List DIOCTYL ETHER
629-82-3

DIOCTYL ETHER synthesis

10synthesis methods
-

Yield:629-82-3 98%

Reaction Conditions:

with Dimethylphenylsilane in 1,1,2,2-tetrachloroethane at 100; for 3 h;

Steps:

2.3 Reductive carbonyl coupling of 1-octanal

1-octanal (1.00 mL, 6.4 mmol), dimethylphenylsilane (1.18 mL, 7.7 mmol, 1.2 eq.), mesitylene (0.30 mL, 2.1 mmol), anhydrous 1,1,2,2-tetrachloroethane (5.0 mL) and CNH/MoO2 (0.040 g, 0.1 mol% Mo) were added to a round bottom flask with Morton indentations in air. The reaction mixture was stirred at 500 rpm and heated to 100 °C for 3 h with a condenser attached. NMR samples were collected and analyzed before and after the reaction. Di-octyl ether was obtained in 98% yield (determined using an internal standard).

References:

Kratish, Yosi;Nakamuro, Takayuki;Liu, Yiqi;Li, Jiaqi;Tomotsuka, Issei;Harano, Koji;Nakamura, Eiichi;Marks, Tobin J. [Bulletin of the Chemical Society of Japan,2021,vol. 94,# 2,p. 427 - 432] Location in patent:supporting information

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