CYCLOPROPANECARBOTHIOAMIDE synthesis
- Product Name:CYCLOPROPANECARBOTHIOAMIDE
- CAS Number:20295-34-5
- Molecular formula:C4H7NS
- Molecular Weight:101.17
6228-73-5
226 suppliers
$5.00/1g
20295-34-5
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$70.00/1 g
Yield: 100%
Reaction Conditions:
with Lawessons reagent;sodium carbonate in tetrahydrofuran at 80; for 2 h;
Steps:
A.1.2; 2
Cyclopropanecarboxamide (115 mmol, 1 eq) was dissolved in THF (500 mL) followed by the addition of Na2CO3 (115 mmol, 1 eq) and LR (115 mmol, 1 eq). The reaction mixture was heated to 80° C. for 2 h and concentrated under reduced pressure. The residue was taken up in diethylether (500 mL) and washed with water (500 mL) and brine (100 mL), dried over MgSO4, filtered and concentrated in vacuo. The product was dried at HV to give cycloporpane thiocarboxamide in quant. yield. LC-MS: tR=0.36 min; [M+H+CH3CN]+=143.18.
References:
Aissaoui, Hamed;Boss, Christoph;Gude, Markus;Koberstein, Ralf;Sifferlen, Thierry US2010/222328, 2010, A1 Location in patent:Page/Page column 12; 22
5500-21-0
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$16.00/5mL
20295-34-5
85 suppliers
$70.00/1 g