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ChemicalBook CAS DataBase List Cyclopentane-1,1-diacetic acid
16713-66-9

Cyclopentane-1,1-diacetic acid synthesis

9synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Inert atmosphere
2.1: triethylamine / dichloromethane / 0.5 h / Inert atmosphere; Cooling
2.2: -3 - 20 °C / Inert atmosphere
3.1: N,N-dimethyl-formamide / 100 °C / Inert atmosphere
4.1: water; sodium hydroxide / ethanol / Inert atmosphere; Reflux

References:

BETA PHARMA CANADA INC;ASTAR BIOTECH LLC;WANG, Zhaoyin;LI, Lianhai WO2013/185202, 2013, A1

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