Citalopram hydrobromide synthesis
- Product Name:Citalopram hydrobromide
- CAS Number:59729-32-7
- Molecular formula:C20H22BrFN2O
- Molecular Weight:405.3
59729-33-8
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59729-32-7
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Yield:59729-32-7 88.2%
Reaction Conditions:
with hydrogen bromide in water;isopropyl alcohol; pH=6 - 7
Steps:
4
10g citalopram obtained in Example3 was heated and dissolved in 40mL isopropanol. After cooled down, pH of the solution was adjusted to 6-7 with bromic acid. The mixture was disposed with active carbon and filtrated, cooled down and placed aside to crystallize. Then the solution was filtrated and washed to give citalopram hydrobromic salt crystal. The obtained salt crystal was recrystallized to give 9.82g citalopram hydrobromic salt crystal with the yield of 88.2% and the purity of 99.9% (HPLC, area normalization method).
References:
Hangzhou Minsheng Pharm. Co., Ltd. EP1700851, 2006, A1 Location in patent:Page/Page column 10
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103146-25-4
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103146-26-5
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64169-67-1
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109-54-6
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59729-32-7
512 suppliers
$5.00/10mg
64169-67-1
148 suppliers
$27.00/1g
59729-33-8
180 suppliers
inquiry
109-54-6
152 suppliers
$9.00/1g
59729-32-7
512 suppliers
$5.00/10mg