Yield:949459-78-3 89%

Reaction Conditions:

Stage #1: methyl (4S,5S)-3-(tert-butoxycarbonyl)-2-(p-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-methanoatewith water;potassium carbonate in methanol at 20; for 20 h;
Stage #2: with hydrogenchloride in methanol;dichloromethane;water at 0; pH=1;

References:

Prevost, Sebastien;Gauthier, Sebastien;De Andrade, Maria Cristina Cano;Mordant, Celine;Touati, Ali Rhida;Lesot, Philippe;Savignac, Philippe;Ayad, Tahar;Phansavath, Phannarath;Ratovelomanana-Vidal, Virginie;Genet, Jean-Pierre [Tetrahedron Asymmetry,2010,vol. 21,# 11-12,p. 1436 - 1446] Location in patent:experimental part