BUPIRIMATE synthesis
- Product Name:BUPIRIMATE
- CAS Number:41483-43-6
- Molecular formula:C13H24N4O3S
- Molecular Weight:316.42
13360-57-1
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$30.00/5g
23947-60-6
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$47.89/250mg
41483-43-6
113 suppliers
$39.29/250mg
Yield:41483-43-6 94%
Reaction Conditions:
with 18-crown-6 ether;potassium carbonate in water;ethyl acetate for 2 h;Reflux;Reagent/catalyst;Solvent;
Steps:
1-10 Example 4
Put 20.9g of ethirimol,15.2g potassium carbonate, 180ml ethyl acetate, 0.018ml water, 0.2% 18-crown-6 were added to the reaction flask in sequence, heated to 50 with stirring, and 17.3g N,N-dimethylsulfonyl chloride was slowly added dropwise. After completion, the temperature was raised to reflux reaction for 2 hours, when the remaining 40% of the raw material was detected, hexamethylenetetramine was added to control the pH of the system to be 10, and the reaction was continued for 4 hours until the end. Then the system is cooled to 50°C, washed with water to adjust the system to neutrality, the water phase is separated, and the solvent is removed to obtain an oily substance. The solid is precipitated at a low temperature to 10°C, dried and weighed 29.7g, which is ethimphenol sulfonate , The yield is 94%, and the content is 97%.
References:
Xi'an Modern Chemical Institute;Wang Wei;Wang Lieping;Liu Kangyun;Huang Xiaoying;Zheng Xiaorui;Ning Binke;Xue Chao CN111303050, 2020, A Location in patent:Paragraph 0028-0050