Boc-Lys(Boc)-OH synthesis
- Product Name:Boc-Lys(Boc)-OH
- CAS Number:2483-46-7
- Molecular formula:C16H30N2O6
- Molecular Weight:346.42
24424-99-5
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10098-89-2
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2483-46-7
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$8.00/5g
Yield:2483-46-7 100%
Reaction Conditions:
with sodium hydroxide in 1,4-dioxane;water at 20;
Steps:
16 Synthesis of Boc-lysine-Boc
To the solution of Lysine HCl salt in 50 ml 1,4-dioxane/H2O (1:1), 1M NaOH is added until pH reaches 10-11. Then Boc anhydride in dioxane (6.0 g in 20 ml dioxane) is added by an addition funnel. The resulting solution is stirred at room temperature overnight. The mixture is concentrated in vacuo and acidified by 4M KHSO4 until pH=1-2. Extract by Ethyl acetate twice and dried in vacuo. Colorless liquid is obtained and yielding is 100%
References:
US2014/127138,2014,A1 Location in patent:Paragraph 0321; 0322
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10098-89-2
200 suppliers
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2483-46-7
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$8.00/5g