Benzotriazole-5-carboxylic acid synthesis
- Product Name:Benzotriazole-5-carboxylic acid
- CAS Number:23814-12-2
- Molecular formula:C7H5N3O2
- Molecular Weight:163.13
619-05-6
291 suppliers
$19.00/25g
23814-12-2
225 suppliers
$6.00/5g
Yield:23814-12-2 91%
Reaction Conditions:
with glacial acetic acid;NaNO2 in lithium hydroxide monohydrate at 0 - 5;Product distribution / selectivity;Cooling with ice-salt;
Steps:
50.1
Step 1. 1H-Benzo[d][1,2,3]triazole-5-carboxylic acid To a solution of 3,4-diaminobenzoic acid (10 g, 65.72 mmol) in AcOH (aq) (150 ml) was added sodium nitrite (5 g, 72.47 mmol) with stirring, and the reaction mixture was stirred overnight at 0-5° C. in an ice/salt bath. The solids were collected by filtration to afford 1H-benzo[d][1,2,3]triazole-5-carboxylic acid as a solid (9.8 g, 91%). LC/MS (ES, m/z):[M+H]+ 153.1 1H-NMR (300 MHz, DMSO) δ 8.53 (s, 1H), 8.01-8.04 (m, 1H), 7.93 (d, J=8.4 Hz, 1H)
References:
US2012/277224,2012,A1 Location in patent:Page/Page column 43
113053-50-2
68 suppliers
$45.00/100mg
23814-12-2
225 suppliers
$6.00/5g
136-85-6
361 suppliers
$10.00/25g
23814-12-2
225 suppliers
$6.00/5g
36692-49-6
243 suppliers
$11.00/5g
23814-12-2
225 suppliers
$6.00/5g
3987-92-6
135 suppliers
$10.00/1g
23814-12-2
225 suppliers
$6.00/5g