ChemicalBook CAS DataBase List BENZENE ACETIC ACID, 4-[(2-CARBOXYPHENYL)METHOXY]

BENZENE ACETIC ACID, 4-[(2-CARBOXYPHENYL)METHOXY] synthesis

6synthesis methods

Product Name:BENZENE ACETIC ACID, 4-[(2-CARBOXYPHENYL)METHOXY]
CAS Number:55453-89-9
Molecular formula:C16H14O5
Molecular Weight:286.28

Benzeneacetic acid, 4-[[2-(methoxycarbonyl)phenyl]methoxy]-, methyl ester

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BENZENE ACETIC ACID, 4-[(2-CARBOXYPHENYL)METHOXY]

55453-89-9
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$20.00/1g

Yield:55453-89-9 83.1%

Reaction Conditions:

Stage #1: 4-(2-methoxycarbonylbenzyloxy)phenyl acetic acidwith N-benzyl-N,N,N-triethylammonium chloride;potassium hydroxide in ethanol; for 3 h;Reflux;Large scale;
Stage #2: with hydrogenchloride in water; pH=1 - 2;Large scale;

Steps:

2.2 Example 2 Step 2. Preparation of intermediate II

The intermediate I (3.2 kg, 10 . 2mol) and 34gTEBA into ethanol, stirring, by adding potassium hydroxide (1.2 kg, 21 . 4mol), heating reflow 3h, evaporate the ethanol, the residue for adding 20L water-soluble. Acidification with concentrated HCl to pH=1-2, generating a large amount of a buff solid, filtered, the filter cake is washed with water to neutral, buff solid obtained after drying 2.42 kg, II as intermediate, yield: 83.1%.

References:

CN104262318,2016,B Location in patent:Paragraph 0053; 0054

87-41-2 Synthesis