ChemicalBook CAS DataBase List Atenolol

Atenolol synthesis

9synthesis methods

Product Name:Atenolol
CAS Number:29122-68-7
Molecular formula:C14H22N2O3
Molecular Weight:266.34

29122-69-8
74 suppliers
$240.00/500mg

75-31-0 Synthesis

75-31-0
429 suppliers
$14.00/25mL

29122-68-7
364 suppliers
$15.00/1g

Yield:29122-68-7 90%

Reaction Conditions:

with Sulfated tungstate at 70; for 0.333333 h;Green chemistry;

Steps:

General procedure for epoxide opening reaction

General procedure: Sulfated tungstate (10 wt%) was added to a solution of cyclohexene oxide (1 g, 10.18 mmol) and aniline (0.95 g, 10.18 mmol) in solvent-free condition and the mixture was stirred at room temperature. The progress of the reaction was monitored by TLC. After the completion of the reaction, the reaction mixture was diluted with ethyl acetate (15 ml) and filtered to recover the catalyst. Organic layer washed with water (10 ml), dried over Na₂SO₄ and concentrated under reduced pressure to give the crude product which was purified by chromatography on silica gel (60-120) with hexane-ethyl acetate (8:2) as eluent to get pure 2-(phenylamino) cyclohexanol as a white solid.

References:

Pathare, Sagar P.;Akamanchi, Krishnacharya G. [Tetrahedron Letters,2013,vol. 54,# 48,p. 6455 - 6459]

29277-73-4 Synthesis