ChemicalBook CAS DataBase List APIGENINTRIACETATE

APIGENINTRIACETATE synthesis

6synthesis methods

Product Name:APIGENINTRIACETATE
CAS Number:3316-46-9
Molecular formula:C21H16O8
Molecular Weight:396.35

520-36-5 Synthesis

520-36-5
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108-24-7
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$14.00/250ML

3316-46-9
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Yield:3316-46-9 94%

Reaction Conditions:

with pyridine at 70; for 6 h;

Steps:

5.1.2 2-(4-Acetoxyphenyl)-4-oxo-4H-chromene-5,7-diyl diacetate (9)

General procedure: Acetic anhydride (1mL, 10.7mmol) was added to a solution of 1 (604mg, 2mmol) in anhydrous pyridine (8mL) at room temperature. The reaction mixture was stirred for 6h at 70°C. After the completion of reaction, the resultant mixture was cooled to room temperature (rt). After concentration, the crude product was recrystallized with acetone to afford 8 as a white solid (973mg, 95% yield).

References:

Li, Bo-Wen;Zhang, Feng-Hua;Serrao, Erik;Chen, Huan;Sanchez, Tino W.;Yang, Liu-Meng;Neamati, Nouri;Zheng, Yong-Tang;Wang, Hui;Long, Ya-Qiu [Bioorganic and Medicinal Chemistry,2014,vol. 22,# 12,p. 3146 - 3158]

10236-47-2 Synthesis