alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol synthesis
- Product Name:alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol
- CAS Number:24155-42-8
- Molecular formula:C11H10Cl2N2O
- Molecular Weight:257.12
46503-52-0
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24155-42-8
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Yield:24155-42-8 98%
Reaction Conditions:
with sodium tetrahydroborate in ethanol at 20; for 12 h;
Steps:
4.6. General procedure for the synthesis of compounds 10a-10b
General procedure: Sodium borohydride (12 g, 0.3 mol) was added to the ethanolsolution (100 mL) of 9a (25.5 g, 0.1 mol). The mixture was stirred at20 °C for 12 h. Then the water was carefully added to the mixture,the white solid was obtained by filtration and recrystallization(EtOH). Yield 98.0%, HRMS m/z: 257.0217[M+H]+. According to thepreparation method of 10a, 9b was used as raw material to preparethe intermediate 10b: white solid, Yield 97.4%, HRMS m/z: 225.0831[M+H]+.
References:
An, Ran;Guo, Chun;Guo, Meng-bi;Hou, Zhuang;Mou, Yan-hua;Su, Xin;Xu, Hang [European Journal of Medicinal Chemistry,2020,vol. 198]
288-32-4
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13692-14-3
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24155-42-8
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288-32-4
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13692-15-4
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4252-78-2
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$9.00/25g
24155-42-8
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2631-72-3
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$14.00/1g
24155-42-8
406 suppliers
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