acetylmethadol synthesis
1synthesis methods
- Product Name:acetylmethadol
- CAS Number:509-74-0
- Molecular formula:C23H31NO2
- Molecular Weight:353.51
Yield:-
Reaction Conditions:
in ethyl acetate
Steps:
6-Dimethylamino-4,4-diphenyl-3-acetoxyheptane. HCl (levo-α-acetyl Methadol. HCl)
6-Dimethylamino-4,4-diphenyl-3-heptanol (435 mg, 1.40 mmol) dissolved in ethyl acetate (10 ml) was treated with acetyl chloride (183 mg, 2.33 mmol). The mixture was refluxed for 2 hours. After allowing the solution to cool to room temperature the solvent was removed under reduced pressure to leave a white foam, this crystallized from ethyl acetate to give 6-dimethylamino-4,4-diphenyl-3-acetoxyheptane.
References:
Salford Ultrafine Chemicals & Research Ltd. US6143933, 2000, A