Alphamethadol synthesis
- Product Name:Alphamethadol
- CAS Number:545-90-4
- Molecular formula:C21H29NO
- Molecular Weight:311.47
1095-90-5
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Yield:-
Reaction Conditions:
with sodium borohydrid in ethanol;ethyl acetate
Steps:
b b)
b) Methadol. To a 20 ml ethanol solution of 1 g of methadone hydrochloride, 0.40 g of sodium borohydride are added. The reaction is kept at room temperature for 2 h. The solvent is evaporated and the residue suspended in ethyl acetate. After washing the organic layer with agueous 10% bicarbonate solution and drying with anhydrous sodium sulfate, the title compound is isolated. ESI-MS 333.4 [M+Na]+
References:
ROLABO SL EP816375, 1998, A1