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ChemicalBook CAS DataBase List Acetosyringone
2478-38-8

Acetosyringone synthesis

11synthesis methods
Preparation by adding a solution of 4-hydroxy-3- iodo-5-methoxyacetophenone and cupric chloride in DMF to a solution of sodium methoxide in methanol and heating between 105° and 120° (86%).
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Yield:2478-38-8 91 %Chromat.

Reaction Conditions:

with iron(III) chloride;oxygen in ethanol at 80; for 6 h;

Steps:

43 Example 43 Synthesis of Compound 43
In an atmospheric pressure oxygen, ferric chloride (0.05 mmol), ene Ic (0.5 mmol), polymethylhydrogensiloxane (2.0 mmol) and ethanol (2.0 mL) were added to the 25 mL reaction flask.After mixing at room temperature, the reaction mixture was reacted at 80 ° C for 6 h.The reaction was completed, aqueous ammonia (0.5 mL) was added and stirred for 1 h.Then, 5 mL of water was added and extracted with ether (5 mL x 3). The organic phases were combined and the solvent was evaporated under reduced pressure. Column chromatography gave 91% yield.

References:

Nanjing Normal University;Han Wei;Liu Binbin;Jin Fengli CN106748690, 2017, A Location in patent:Paragraph 0154; 0155; 0156

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