ChemicalBook CAS DataBase List 1,2-Diphenyl-1-[4-[2-(Dimethylamino) Ethoxy]-Phenyl] Butane-4-Ol

1,2-Diphenyl-1-[4-[2-(Dimethylamino) Ethoxy]-Phenyl] Butane-4-Ol synthesis

4synthesis methods

Product Name:1,2-Diphenyl-1-[4-[2-(Dimethylamino) Ethoxy]-Phenyl] Butane-4-Ol
CAS Number:97151-03-6
Molecular formula:C26H29NO2
Molecular Weight:387.51

gamma-[(4-Hydroxyphenyl)phenylmethylene]benzenepropanol

89778-37-0
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2-Dimethylaminoethyl chloride hydrochloride

4584-46-7
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$19.73/100g

1,2-Diphenyl-1-[4-[2-(Dimethylamino) Ethoxy]-Phenyl] Butane-4-Ol

97151-03-6
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Yield:97151-03-6 98%

Reaction Conditions:

with potassium carbonate in acetone at 25 - 50; for 5 h;Solvent;Reagent/catalyst;Temperature;

Steps:

1 Synthesis of Compound F configuration Z

Acetone was added to the 2L reactor 1L flask, 100g (0. 32mol) obtained in the above step D Z configuration andcompound 265. 3g (l. 92mol) of potassium carbonate to form a fourth hybrid system, the control system of the fourth mixingtemperature below 25 ° C, the fourth to the mixed system was slowly added 67.2g (0.48m l) 2(N, Ndimethylamino)ethyl chloride hydrochloride (C1CH2CH2N (CH 3) 2 · HC1), completion of the formation of a fifth mixed system was added,the mixture system was heated to a fifth 50 ° C, 5 hours after the reaction, the reaction was stopped to obtain a secondproduct system, the second product is cooled to 15~25 ° C and filtered, The filtrate obtained was concentrated to obtain aconcentrated product, was added to the concentrated product 1L of ethyl acetate and the combined organic solution wasformed by mixing the abovedescribedwater 2L organic solution was washed twice with a mixture of oil and water is formed,to carry out a liquid mixture of oil and water, and the resulting organic phase concentrated to give 120g Z configurationcompound F, a calculation of Zconfigurationcompound yield of 98% F, F detected by the compound Z configuration ofpurity 95.4%

References:

CN104230723,2016,B Location in patent:Paragraph 0049; 0052; 0053

1137-42-4 Synthesis