(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride synthesis
- Product Name:(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride
- CAS Number:866783-13-3
- Molecular formula:C12H18ClNO2
- Molecular Weight:243.73
866783-12-2
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866783-13-3
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$50.00/100mg
Yield:866783-13-3 95%
Reaction Conditions:
Stage #1: [{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)aminewith acetic acid in ethanol at 20; for 0.5 h;
Stage #2: with hydrogenchloride at 15 - 20; for 1 h;
Steps:
1.4.C Step C: (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride
The (1S)-4,5-dimethoxy-1-[(methylamino)methyl]benzocyclobutane obtained in the previous step was dissolved in acetic acid.Ethyl (20ml)And Ethanol (5ml)In the mixed solution,Stir at 20°C for 30 minutes,Then pass hydrogen chloride gas into the liquid,The turbid liquid will be stirred at 15°C20°C for 1h.Suction filtrationWash with a mixture of ethyl acetate/ethanol = 4:1,Dry (1S)-4,5-dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride (2.38 g, 95%)
References:
CN104557573,2018,B Location in patent:Paragraph 0109; 0116; 0121; 0122
![(S)-3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid N-methyl-amide](/CAS/20200515/GIF/1220993-43-0.gif)
1220993-43-0
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866783-13-3
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![Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S,4R)-, compd. with (7S)-3,4-dimethoxy-N-methylbicyclo[4.2.0]octa-1,3,5-triene-7-methanamine (1:1)](/CAS/20211123/GIF/1031767-75-5.gif)
1031767-75-5
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866783-13-3
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$50.00/100mg
148870-55-7
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866783-13-3
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35202-54-1
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866783-13-3
261 suppliers
$50.00/100mg