ChemicalBook CAS DataBase List 1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione

1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione synthesis

11synthesis methods

Product Name:1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione
CAS Number:830346-47-9
Molecular formula:C13H10F4N2O2
Molecular Weight:302.22

626-48-2 Synthesis

626-48-2
384 suppliers
$10.00/25 g

2-FLUORO-6-(TRIFLUOROMETHYL)BENZYL BROMIDE

239087-08-2
206 suppliers
$14.00/1g

1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione

830346-47-9
188 suppliers
$24.00/100mg

Yield:830346-47-9 89%

Reaction Conditions:

with tetra-(n-butyl)ammonium iodide;potassium carbonate in N,N-dimethyl-formamide at 70; for 18 h;Solvent;Reagent/catalyst;Temperature;

Steps:

1-6 Example 1
In the reactor, 1.0 g, 1.0 equiv. as shown in Formula IV2-(Bromomethyl)-1-fluoro-3-(trifluoromethyl)benzene was dissolved in 10 mL of DMF.To this was added 1.2 equiv. 6-methyluracil as shown in Formula V, 1.8 equiv. potassium carbonate,0.1equiv. of TBAI, the system is heated to 70 ° C for 18h;After the reaction was completed, the reaction mixture was concentrated to dryness, and the concentrate was washed with a mixture of dichloromethane and 1N aqueous hydrochloric acid.The organic phase is separated, and the organic phase is washed successively with a saturated aqueous solution of sodium hydrogencarbonate and brine.Subsequently, it is dried over sodium sulfate and spin-dried to obtain 0.89 equiv. of the polysubstituted pyrimidine derivative as shown in Formula I.The yield was 89%.

References:

Anhui Nuoquan Pharmaceutical Co., Ltd.;Liu Haijie;Hu Zhigang;Xu Liangzhi;He Darong;Du Xiaopeng;Qian Zhujin;He Yong CN109761911, 2019, A Location in patent:Paragraph 0024-0037

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