8-Bromooctanoic acid synthesis
- Product Name:8-Bromooctanoic acid
- CAS Number:17696-11-6
- Molecular formula:C8H15BrO2
- Molecular Weight:223.11
29823-21-0
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$10.00/1g
17696-11-6
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$13.00/1g
Yield:17696-11-6 97%
Reaction Conditions:
with water;sodium hydroxide in ethanol at 0; for 5 h;
Steps:
8-Bromooctanoic Acid (17)
To a solution of ethyl 8-bromooctanoate (1.0 g, 3.98mmol) in EtOH (10 mL), 1M NaOH (3.98 mL) was addeddropwise, and the resulting mixture was stirred at 0°C for 5h. The mixture was acidified with 1M HCl and extractedwith ethyl acetate (3 10 mL). The organic layer waswashed with satd NaHCO3 (2 20 mL) and brine (2 20mL), dried over Na2SO4, filtered, and concentrated to getcompound 17 as colorless oil 0.86 g, yield 97%.
References:
Zhang, Liying;Dong, Jizhe;Zhang, Yingxia;Liu, Jun;Zhang, Luyong;Sun, Hongbin [Medicinal Chemistry,2013,vol. 9,# 2,p. 294 - 302]
50816-19-8
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17696-11-6
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$13.00/1g
50816-20-1
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$42.60/1g
17696-11-6
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$13.00/1g
629-41-4
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$9.00/10g
17696-11-6
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$13.00/1g
6557-85-3
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17696-11-6
316 suppliers
$13.00/1g