![70500-72-0](/CAS/GIF/70500-72-0.gif)
7-Hydroxyquinolinone synthesis
- Product Name:7-Hydroxyquinolinone
- CAS Number:70500-72-0
- Molecular formula:C9H7NO2
- Molecular Weight:161.16
![3,4-Dihydro-7-hydroxy-2(1H)-quinolinone](/CAS/GIF/22246-18-0.gif)
22246-18-0
624 suppliers
$5.00/5g
![7-Hydroxyquinolinone](/CAS/GIF/70500-72-0.gif)
70500-72-0
424 suppliers
$6.00/250mg
Yield:70500-72-0 90.9%
Reaction Conditions:
with palladium 10% on activated carbon in decalin at 180; for 8 h;
Steps:
1-7 Example 2:
100 g of 3,4-dihydro-7-hydroxy-2-quinolinone was added to a 3000 mL reaction flask, 2000 mL of decalin was added, and 10 g of 10% palladium carbon was finally added. The mixture was heated to 180 °C, stirred under reflux for 8 hours, cooled to room temperature, and 400 mL of a 2 mol/L sodium hydroxide solution was added thereto and the catalyst was filtered off. The separated aqueous layer was further added with 80 ml of a 10 mol/L hydrochloric acid solution and dried by filtration to obtain 89.7 g of an off-white powder of 7-hydroxy-2-quinolinone in a yield of 90.9%, purity (HPLC) 98.9%.
References:
Shanghai Pharmaceutical Industry Institute;China Pharmaceutical Industry Zongyuan;Zheng Zhiwei;Sui Qiang;Jiang Kaiyuan;Tang Chao;Gao Qi;Liu Shuai;Chen Jianli;Li Gen CN109776408, 2019, A Location in patent:Paragraph 0030-0043; 0047; 0048
![N-(CINNAMOYL)-3-METHOXYANILINE](/StructureFile/ChemBookStructure22/GIF/CB4648626.gif)
127033-74-3
55 suppliers
$10.00/1g
![7-Hydroxyquinolinone](/CAS/GIF/70500-72-0.gif)
70500-72-0
424 suppliers
$6.00/250mg
![(E)-N-(3-METHOXY-PHENYL)-3-PHENYL-ACRYLAMIDE](/CAS/GIF/15116-41-3.gif)
15116-41-3
36 suppliers
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![7-Hydroxyquinolinone](/CAS/GIF/70500-72-0.gif)
70500-72-0
424 suppliers
$6.00/250mg
![3-Aminophenol](/CAS/GIF/591-27-5.gif)
591-27-5
544 suppliers
$11.00/10g
![7-Hydroxyquinolinone](/CAS/GIF/70500-72-0.gif)
70500-72-0
424 suppliers
$6.00/250mg
![m-Anisidine](/CAS/GIF/536-90-3.gif)
536-90-3
303 suppliers
$10.00/5g
![7-Hydroxyquinolinone](/CAS/GIF/70500-72-0.gif)
70500-72-0
424 suppliers
$6.00/250mg