ChemicalBook CAS DataBase List 7-Bromoquinolin-8-ol

7-Bromoquinolin-8-ol synthesis

4synthesis methods

Product Name:7-Bromoquinolin-8-ol
CAS Number:13019-32-4
Molecular formula:C9H6BrNO
Molecular Weight:224.05

148-24-3 Synthesis

148-24-3
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13019-32-4
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$23.00/250mg

Yield: 85%

Reaction Conditions:

with N-Bromosuccinimide in chloroform at 0 - 40; for 18 h;

Steps:

Synthesis of 7-bromoquinolin-8-ol (2)
To a stirred solution of quinolin-8-ol (1) (5 g, 1 mmol) in chloroform (10 mL), N-bromo succinimide (6.13 g, 1 mmol) was added portion wise at 0 °C, slowly raising the temperature to 40 °C and stirred for 18 h. The progress of the reaction was monitored by TLC using ethyl acetate and hexane as an eluent (1:9). After completion of the reaction, the reaction mixture was evaporated under vacuum and washed with water to give the crude 7-bromoquinolin-8-ol (2) (6.53 g), which was then washed with hexane and diethyl ether to yield 7-bromoquinolin-8-ol as a white solid in 85% yield. m.p: 138-143 °C; EI-MS: m/z (%): 224 (M+ H (100)), 145 (32).

References:

Krishna, Palaa [Phosphorus, Sulfur and Silicon and the Related Elements,2018,vol. 193,# 10,p. 685 - 690]

148-24-3 Synthesis

148-24-3
826 suppliers
$5.00/25g