ChemicalBook CAS DataBase List Iodoform

Iodoform synthesis

14synthesis methods

Product Name:Iodoform
CAS Number:75-47-8
Molecular formula:CHI3
Molecular Weight:393.73

109-73-9 Synthesis

109-73-9
453 suppliers
$9.00/1g

98-86-2 Synthesis

98-86-2
772 suppliers
$9.00/5g

75-47-8
249 suppliers
$19.00/25g

2782-40-3
23 suppliers
$470.00/1g

Yield:2782-40-3 85% ，75-47-8 30%

Reaction Conditions:

with tert.-butylhydroperoxide;iodine in water;Petroleum ether at 0; for 12 h;Reagent/catalyst;Solvent;

Steps:

General procedures for amides 3
General procedure: Methyl ketones (0.5mmol), ammines (2.0mmol), I₂ (0.55mmol, 110mol%), TBHP (6.0equiv, 70% aqueous solution 401 uL), and 2.0mL of PE, were added to a tube under air. The reaction mixture was stirred at 0°C for 12h. The reaction mixture was quenched with saturated Na₂S₂O₃ solution, extracted repeatedly with ethyl acetate, dried over Na₂SO₄. It was then removal of the organic solvent in vacuum and followed by flash silica gel column chromatographic purification afforded product with Petroleum/Ethyl acetate mixtures.

References:

Zhu, Chunyin;Wei, Wei;Du, Peng;Wan, Xiaobing [Tetrahedron,2014,vol. 70,# 51,p. 9615 - 9620]

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