7-Aminoisoquinoline synthesis
- Product Name:7-Aminoisoquinoline
- CAS Number:23707-37-1
- Molecular formula:C9H8N2
- Molecular Weight:144.17
13058-73-6
75 suppliers
$56.00/250mg
23707-37-1
109 suppliers
$29.00/100mg
Yield: 90%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in methanol at 20; for 24.5 h;
Steps:
1 Synthesis of isoquinolin-7-amine (31-4)
Synthesis of isoquinolin-7-amine (31-4)
To a suspend solution of Pd/C (10%, 100 mg) in methanol (20 mL) was added 31-3 (200 mg, 1.15 mmol) in methanol (40 mL).
After having been degassed and recharged with hydrogen, the mixture was then stirred at room temperature for 24.5 h. TLC showed that the reaction was complete.
The Pd/C was removed by filtration and the solvent was evaporated.
The residual was used without further purification (150 mg, yield 90%).
References:
Nivalis Therapeutics, Inc.;Wasley, Jan;Rosenthal, Gary J.;Sun, Xicheng;Strong, Sarah;Qiu, Jian US9138427, 2015, B2 Location in patent:Page/Page column 307
42923-79-5
124 suppliers
$15.00/250mg
23707-37-1
109 suppliers
$29.00/100mg
7651-83-4
155 suppliers
$24.00/100mg
23707-37-1
109 suppliers
$29.00/100mg
91-21-4
256 suppliers
$5.00/5g
23707-37-1
109 suppliers
$29.00/100mg
3230-65-7
79 suppliers
$29.00/100mg
23707-37-1
109 suppliers
$29.00/100mg