7-NITRO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE synthesis
- Product Name:7-NITRO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
- CAS Number:42923-79-5
- Molecular formula:C9H10N2O2
- Molecular Weight:178.19
91-21-4
257 suppliers
$5.00/5g
42923-79-5
124 suppliers
$15.00/250mg
Yield:42923-79-5 86%
Reaction Conditions:
with sodium nitrate;sulfuric acid at 4 - 20; for 16 h;
Steps:
5 2-Allyl- 1 -(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-((2-methyl- 1,2,3 ,4-tetrahydroisoquinolin-7-yl)amino)- 1 ,2-dihydro-3H-pyrazolo[3 ,4-d]pyrimidin-3-one
To concentrated H2504 solution (62 mL) at 4 °C was added 1,2,3,4- tetrahydroisoquinoline (15 g, 112.78 mmol) dropwise keeping the temperature below 15 °C. To the stifling mixture at 4 °C was added NaNO3 (12.5, 148.80 mmol) keeping internal temperature below 10 °C. The reaction mixture was stined at RT for 16 h. The reaction mixture was added to NH4OH (185 mL) to a final pH = 8. The mixture was extracted with DCM (3 x 150 mL), washed with brine (75 mL) and dried (Na2504). The solvent was removed. The resulting crude was dissolved in EtOH (50 mL) and concentrated HC1 (14 mL) was added. The resulting solid was filtered and washed with diethyl ether to afford 7-nitro- 1,2,3,4-tetrahydroisoquinoline (13 g, 86%) as a mixture of isomers. MS (ESI) mlz: 179.1 [M+H].
References:
WO2019/28008,2019,A1 Location in patent:Paragraph 0141
181514-37-4
5 suppliers
inquiry
42923-79-5
124 suppliers
$15.00/250mg
91-21-4
257 suppliers
$5.00/5g
42923-79-5
124 suppliers
$15.00/250mg
186390-77-2
54 suppliers
inquiry
![Acetamide, 2,2,2-trifluoro-N-[2-(4-nitrophenyl)ethyl]-](/CAS/20200515/GIF/24954-63-0.gif)
24954-63-0
1 suppliers
inquiry
42923-79-5
124 suppliers
$15.00/250mg
64-04-0
0 suppliers
$10.00/5mL
42923-79-5
124 suppliers
$15.00/250mg