ChemicalBook CAS DataBase List 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)uridine

3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)uridine synthesis

8synthesis methods

Product Name:3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)uridine
CAS Number:69304-38-7
Molecular formula:C21H38N2O7Si2
Molecular Weight:486.71

69304-37-6 Synthesis

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

69304-37-6
299 suppliers
$10.00/1g

58-96-8 Synthesis

58-96-8
652 suppliers
$5.00/1g

3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)uridine

69304-38-7
58 suppliers
$19.00/250mg

Yield: 100%

Reaction Conditions:

with pyridine at 20; for 16 h;Cooling with ice;

Steps:

58 Example 58
To an ice cooled solution of 82-1 (50 g, 204.9 mmol) in dry Py (400 mL) was added TIPDSCl (70.78 g, 225.4 mmol) dropwise. The mixture was stirred at R.T. for 16 h, and then concentrated at low pressure. The residue was purified by chromatography using 20% EA in PE to generate 82-2 (111.5 g, 100%) as a white solid.

References:

ALIOS BIOPHARMA, INC.;Beigelman, Leonid;Wang, Guangyi;Smith, David Bernard US2014/179627, 2014, A1 Location in patent:Paragraph 0565