ChemicalBook CAS DataBase List 6-(METHYLAMINO)PURINE

6-(METHYLAMINO)PURINE synthesis

9synthesis methods

Product Name:6-(METHYLAMINO)PURINE
CAS Number:443-72-1
Molecular formula:C6H7N5
Molecular Weight:149.15

87-42-3
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$14.00/25g

74-89-5 Synthesis

74-89-5
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443-72-1
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$39.00/50mg

Yield: 90%

Reaction Conditions:

in methanol;ethanol at 120; for 4 h;Sealed tube;

Steps:

147.A
Example 147 1-[4-(6-(Methylamino)purin-9-yl)phenyl]-3-[3-(4-methylpiperazin-1-ylmethyl)-5-(trifluoromethyl)-phenyl]urea (Table 2, Compound 25) Step A Preparation of methyl-(9H-purin-6-yl)amine [Show Image] [Show Image] In 20 mL of a 40% methylamine methanol solution and 20 mL of ethanol, 12.5 g (79 mmol) of 6-chloropurin was dissolved and the solution was sealed in a tube and stirred in the tube at 120°C for four hours. The reaction solution was concentrated, and then triturated with water and collected on a filter, washed with water, and then vacuum dried to obtain 10.78 g (90%) of methyl-(9H-purin-6-yl)amine as a white solid. ¹H-NMR (270 MHz, DMSO-d₆) δ (ppm): 2.98(3H,br.s), 7.58(1H,br.s), 8.06(1H,s), 8.19(1H,br.s), 12.89(1H,br.s) ESI (LC-MS positive mode) m/z 150 (M+H)

References:

CHUGAI SEIYAKU KABUSHIKI KAISHA EP1724258, 2006, A1 Location in patent:Page/Page column 138