ChemicalBook CAS DataBase List 6-METHOXY-1,2,3,4-TETRAHYDRO-BETA-CARBOLINE

6-METHOXY-1,2,3,4-TETRAHYDRO-BETA-CARBOLINE synthesis

11synthesis methods

Product Name:6-METHOXY-1,2,3,4-TETRAHYDRO-BETA-CARBOLINE
CAS Number:20315-68-8
Molecular formula:C12H14N2O
Molecular Weight:202.25

tert-butyl 6-methoxy-1,3,4,9-tetrahydro-2H-beta-carboline-2-carboxylate

1029578-08-2
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6-METHOXY-1,2,3,4-TETRAHYDRO-BETA-CARBOLINE

20315-68-8
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$55.00/10mg

Yield: 99%

Reaction Conditions:

with hydrogenchloride in methanol at 20; for 2 h;

Steps:

11.2 Step 2) 6-methoxy-1,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
6-methoxy-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylic acid tert-butyl ester (0.30 g, 0.99 mmol) was dissolved in methanol (0.5 mL).Add methanol solution of hydrogen chloride (5 mL, 3.0 mol/L),The reaction was carried out for 2 hours at room temperature. The reaction solution was adjusted to pH=8 with sodium bicarbonate solid. Filtered, the filtrate was concentrated, residual solids by silica gel column chromatography [Dichloromethane/methanol (v/v) = 9/1] purified, the title compound was obtained (0.20 g, yield 99%). It is a black solid.

References:

Guangdong Dongyangguang Pharmaceutical Co., Ltd.;Ruyuan Yong Xing Technology Services Co., Ltd.;Li Jianhao;Gu Zheng;Tang Wanjun;Kang Panpan;Zhang Zongyuan;Deng Xinshan;Wang Xuli CN109928971, 2019, A Location in patent:Paragraph 0355; 0359; 0360

50-00-0 Synthesis