ChemicalBook CAS DataBase List 5-Methyl-2-pyrazinecarboxylic acid

5-Methyl-2-pyrazinecarboxylic acid synthesis

12synthesis methods

Product Name:5-Methyl-2-pyrazinecarboxylic acid
CAS Number:5521-55-1
Molecular formula:C6H6N2O2
Molecular Weight:138.12

5-Methylpyrazine-2-carboxylic acid is an intermediate of the lipid-lowering drug amoximus. It can be prepared by electrolytic oxidation of 2,5-dimethyl or 2-methyl-5-(substituted) methylpyrazine.

51037-30-0 Synthesis

51037-30-0
280 suppliers
$5.00/50mg

5521-55-1
449 suppliers
$9.00/5g

Yield:5521-55-1 88.6%

Reaction Conditions:

with pyrographite in lithium hydroxide monohydrate at 100; for 0.333333 h;

Steps:

2 Comparative Example 2:

Add 200ml of water to 100g of crude axilimus, heat to 100°C, stir and dissolve, add 3.0g of activated carbon, continue to keep stirring for 20 minutes, suction filtration; cool the filtrate to 60°C at 10°C/h, then add dropwise to it 220g of acetone, after dripping, was cooled to 5°C for 7 hours at 10°C/h, filtered with suction, washed with acetone and the filter cake was dried (0.01MPa, 80°C) to obtain off-white axilimus. The yield was 88.6%.HPLC purity: 98.3%, 5-methylpyrazine-2-carboxylic acid (impurity I): 0.5%.

References:

CN109438370,2022,B Location in patent:Paragraph 0067-0068

123-32-0 Synthesis