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ChemicalBook CAS DataBase List Pyrazine
290-37-9

Pyrazine synthesis

12synthesis methods
Prepared by cyclization of α-amino ketones, which were produced by the reduction of isonitroso ketones to yield the dihydropyrazines, which are dehydrogenated with mercury(I) oxide or copper(II) sulfate or sometimes with atmospheric oxygen.
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Yield:-

Steps:

S.8 SPECIFIC EXAMPLE 8
SPECIFIC EXAMPLE 8 Ethanolamine was subjected to a reaction as described in Example 7 and the reactor temperature was at 300°C. Pyrazine was obtained as the major cyclocondensation product.

References:

TEXACO DEVELOPMENT CORPORATION EP363532, 1990, A1

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