ChemicalBook CAS DataBase List 5-METHOXY-1H-INDOLE-2-CARBOXYLIC ACID METHYL ESTER

5-METHOXY-1H-INDOLE-2-CARBOXYLIC ACID METHYL ESTER synthesis

10synthesis methods

Product Name:5-METHOXY-1H-INDOLE-2-CARBOXYLIC ACID METHYL ESTER
CAS Number:67929-86-6
Molecular formula:C11H11NO3
Molecular Weight:205.21

67-56-1 Synthesis

67-56-1
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$9.00/25ml

4382-54-1 Synthesis

4382-54-1
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$10.00/250mg

5-METHOXY-1H-INDOLE-2-CARBOXYLIC ACID METHYL ESTER

67929-86-6
57 suppliers
$120.00/1g

Yield:67929-86-6 98.7%

Reaction Conditions:

with sulfuric acid for 6 h;Reflux;

Steps:

30.a

A mixture of 9.6 g (0.050 mol) of 5-methoxy-lH-indole-2-carboxylic acid and 4.5 mL of concentrated sulfuric acid in 250 mL of methanol was refluxed for 6 h. The reaction mixture was cooled, concentrated in vacuo and 200 mL of water and 200 mL of dichloromethane was added to the residue. The organic layer was separated and the water phase was extracted with 100 mL of dichloromethane. The combined organic layers were washed with water and saturated sodium hydrogencarbonate solution, dried over sodium sulfate, concentrated and dried to yield 10.17 g (98.7 %) of the title compound. Mp: 178-181 °C.

References:

WO2012/59776,2012,A1 Location in patent:Page/Page column 57