5-Hydroxyindole synthesis
- Product Name:5-Hydroxyindole
- CAS Number:1953-54-4
- Molecular formula:C8H7NO
- Molecular Weight:133.15
1006-94-6
489 suppliers
$10.00/5g
1953-54-4
371 suppliers
$12.00/1g
Yield:1953-54-4 71%
Reaction Conditions:
with 1-N-ferrocenylmethyl benzimidazole tagged polymer in N,N-dimethyl-formamideReflux;
Steps:
Typical procedure for O-demethylation
General procedure: A mixture of aryl methyl ether (1 mmol) and [FemMerBenz]Al2Cl7 (200 mg, 0.96 mol %) in DMF (5 mL) was refluxed in an oil bath. After completion of the reaction as monitored by the TLC, the reaction mixture was cooled and filtered. The filtrate was poured into water (20 mL) and extracted with ethyl acetate (3 20 mL). The combined organic layers were dried over Na2SO4. Evaporation of the solvent followed by column chromatography over silica gel using ethyl acetate/ petroleum ether (1:4 v/v) afforded pure O-demethylated product, which was characterized by spectral methods.
References:
Kurane, Rajanikant;Gaikwad, Vipul;Jadhav, Jagannath;Salunkhe, Rajashri;Rashinkar, Gajanan [Tetrahedron Letters,2012,vol. 53,# 47,p. 6361 - 6366,6]
![1-[2-(5-BENZYLOXY-2-NITROPHENYL)VINYL]PYRROLIDINE](/StructureFile/ChemBookStructure7/GIF/CB1712320.gif)
1215-59-4
335 suppliers
$10.00/1g
1953-54-4
371 suppliers
$12.00/1g
144104-59-6
234 suppliers
$20.00/1g
1953-54-4
371 suppliers
$12.00/1g
172078-33-0
74 suppliers
$97.00/250mg
98-95-3
12 suppliers
$14.00/25g
1953-54-4
371 suppliers
$12.00/1g
62-53-3
658 suppliers
$10.00/1g