ChemicalBook CAS DataBase List 5-Hydroxy-6-methoxy-1-indanone

5-Hydroxy-6-methoxy-1-indanone synthesis

4synthesis methods

Product Name:5-Hydroxy-6-methoxy-1-indanone
CAS Number:127399-78-4
Molecular formula:C10H10O3
Molecular Weight:178.18

3-(3-HYDROXY-4-METHOXYPHENYL)PROPIONIC ACID

1135-15-5
46 suppliers
$84.00/250mg

127399-78-4
55 suppliers
$384.00/250mg

Yield:127399-78-4 95%

Reaction Conditions:

with trifluorormethanesulfonic acid at 0 - 20; for 2.5 h;

Steps:

4.1.1. General synthesis procedures for 2,3-dihydroinden-1-ones 14a-b

General procedure: A solution of compound 13 (3.0 g, 16 mmol) in trifluoromethanesulfonicacid (14 mL) was stirred at 0 C for 0.5 h, thenthe solution was warmed to room temperature and stirred for 2 h. Afterthe reaction was complete, the solution was poured into ice water (50mL). After the solid was precipitated entirely from the water, themixture was filtered to afford a light pink solid, which was washed withdistilled water (10 mL) three times, and dried to obtain a pink solidpowder.

References:

Liu, Jie;Liu, Lu;Zheng, Lei;Feng, Kai-Wen;Wang, Hai-Tao;Xu, Jiang-Ping;Zhou, Zhong-Zhen [European Journal of Medicinal Chemistry,2022,vol. 238,art. no. 114503]

2107-69-9 Synthesis