5-chloro-3-methyl-3H-imidazo[4,5-b]pyridine synthesis
- Product Name:5-chloro-3-methyl-3H-imidazo[4,5-b]pyridine
- CAS Number:83472-65-5
- Molecular formula:C7H6ClN3
- Molecular Weight:167.6
89660-14-0
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149-73-5
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83472-65-5
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Yield:83472-65-5 81.6%
Reaction Conditions:
with toluene-4-sulfonic acid at 22; for 3 h;Reflux;
Steps:
3 Step 3: 5-Chloro-3-methyl-3H-imidazo[4,5-b]pyridine
To a solution of 6-chloro-N2-methylpyridine-2,3-diamine (300 mg, 1.9 mmol) in HC(OMe)3 (10 mL) was added TsOH (10 mg) at 22°C. The mixture was stirred for 3 h under reflux until TLC (PE: EA =3: 1) showed that the reaction was complete. The mixture was concentrated to get the crude material which was purified by using column chromatography on silica gel to give the desired product (261 mg, 81.6%) as an oil. LCMS (m/z): 168.1
References:
WO2014/100695,2014,A1 Location in patent:Paragraph 00396
![3H-Imidazo[4,5-b]pyridine, 4-oxide](/CAS/GIF/6863-46-3.gif)
6863-46-3
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273-21-2
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16013-85-7
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33742-70-0
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83472-65-5
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