5-Bromothiophene-2-carbaldehyde synthesis

10synthesis methods

Product Name:5-Bromothiophene-2-carbaldehyde
CAS Number:4701-17-1
Molecular formula:C5H3BrOS
Molecular Weight:191.05

98-03-3 Synthesis

98-03-3
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$5.00/25g

4701-17-1
298 suppliers
$6.00/1g

Yield:4701-17-1 98%

Reaction Conditions:

with N-Bromosuccinimide in chloroform at 20;

Steps:

2.1.1 Synthesis processes of BDY-3T-BDY
2.1.1
Synthesis of 5-bromo-2-thiophenecarbaldehyde
To a solution of 2-thiophenecarboxaldehyde (6.0 g, 53.5 mol) in anhydrous CHCl₃ (125 mL), N-bromosuccinimide (10.4 g, 58.9 mmol) was slowly added, and then the reaction mixture was stirred for overnight at room temperature.
The reaction mixture was extracted with CHCl₃, and the organic phase was washed with deionized water, dried over Na₂SO₄, filtered, and evaporated to dryness to give the crude product.
Column chromatography was performed on silica gel using CHCl₃ as the eluent, which affords the pure product as a colorless oil (10.0 g, 98%).
¹H NMR (400 MHz, CDCl₃): δ 7.20 (d, H, J = 4.0 Hz), 7.53 (d, H, J = 8.0 Hz), 9.79 (s, H).

References:

Tataro?lu;Al-Sehemi, Abdullah G.;?zdemir, Mehmet;?zdemir, Resul;Usta, Hakan;Al-Ghamdi, Ahmed A.;Farooq;Yakuphanoglu [Physica B: Condensed Matter,2017,vol. 519,p. 53 - 58]

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765-58-2 Synthesis