5-Bromo-2-nitrobenzotrifluoride synthesis

5synthesis methods

Product Name:5-Bromo-2-nitrobenzotrifluoride
CAS Number:344-38-7
Molecular formula:C7H3BrF3NO2
Molecular Weight:270

320-38-7 Synthesis

4-NITRO-3-(TRIFLUOROMETHYL)BENZOIC ACID&

320-38-7
60 suppliers
$20.00/250mg

344-38-7
228 suppliers
$10.00/5g

Yield: 79%

Reaction Conditions:

with trichloroisocyanuric acid;bromine in tetrachloromethane;chloroform at 10 - 100; for 18 h;Photolysis;

Steps:

4 Bromodecarboxylation of nitroarenecarboxylic acids
General procedure: A 25 mL round bottom flask equipped with Dimroth condenser (chilled to 10 °C) was charged with nitroarenecarboxylic acid ArC0₂H (1.8 mmol), chloroisocyanurate, brominating agent and solvent (8 mL). The mixture was stirred and heated in an oil bath under fluorescent room light irradiation (FL). The cooled reaction mixture was filtered through short silica gel pad, washed with 1 M aq Na₂S0₃, dried over Na₂S0₄, filtered and concentrated in vacuo to obtain bromonitroarene ArBr. The obtained product contained between 1-5% of the corresponding chloronitroarene ArCl as a by-product. The results are presented in Table 2. Table 2. Bromodecarboxylation of nitroarenecarboxylic acids ArC0₂H ^a

References:

TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED;GANDELMAN, Mark;NISNEVICH, Gennady A.;KULBITSKI, Kseniya;ARTARYAN, Alexander WO2017/60906, 2017, A1 Location in patent:Paragraph 00122

401-78-5 Synthesis